May 4, 2014

Geisinger investigators study hepatitis C infection rates in Vietnam era veterans

New research finds Vietnam vets with hepatitis C do not have higher rates of the disease

DANVILLE, Pa., May 2, 2014 /PRNewswire-USNewswire/ -- A team of researchers from four health systems across the United States has published a study revealing that Vietnam era vets with hepatitis C virus (HCV) do not have higher rates of this disease due to injection drug abuse compared to nonveterans. The study was published electronically in the Journal of Community Health in April.

It is estimated that 3.2 million Americans have chronic HCV infections, and compared to HIV, the medical community knows little about the spectrum of the disease, access to care and the effectiveness of current therapies.

The purpose of the current study was to assess reported risk factors for HCV among U.S. Military veterans from the Vietnam era compared to nonveterans. Past studies among mostly Veterans Health Administration (VA) medical facility patients have suggested that Vietnam era veterans have a higher prevalence of the infection primarily due to higher rates of injection drug abuse, a known risk factor for HCV infection.

"The issue of hepatitis C and its link to Vietnam veterans has been a sore issue with these veterans for at least a decade," said study author Joseph Boscarino, Ph.D., MPH, a senior scientist with the Geisinger Health System Center for Health Research and study site director at Geisinger. "We decided to take a different approach and study patients who sought treatment outside of the VA. Since previous veteran studies typically looked at patients treated in VA facilities, our hypothesis was that Vietnam era veterans do not have higher rates of this disease to due drug abuse than nonveterans.

"Since most veterans do not use the VA healthcare system and studies of Vietnam veterans in the community have suggested that they actually had lower rates of drug abuse than nonveterans, we were confident of our hypothesis," Boscarino added. 

Dr. Boscarino's study analyzed records of more than 2 million patients to obtain a random survey of 4,636 patients with laboratory-confirmed HCV disease. A total of 2,633 male respondents with HCV infection were included in his analyses. Females with HCV were excluded from these analyses, because less than 2% were veterans. The final analysis included 526 Vietnam era veterans (those who served in the military anytime between 1964 and 1975), compared to 1,812 non-veterans. The comparison yielded no major common risk factors pointing to a Vietnam era link to hepatitis C infection.

"Of all the known risk factors associated with hepatitis C, including injection drug use, occupational exposures, sexual contacts or blood transfusions before 1992, there was little to no variation between how Vietnam era veterans and nonveterans reported contracting HCV infection," said. Dr. Boscarino. "The one exception, however, was that the veterans were significantly more likely to report they got their HCV infection though 'other' sources, than the nonveterans. When asked what these 'other' sources were, vets typically reported they were 'shots' or 'vaccinations' they received in the military.

"While the issue of 'shots' or 'vaccinations' received in the military being the cause of HCV infection among Vietnam vets is yet to be proven, it is clear that the most significant risk factor – having a history of injection drug abuse – is not higher among the vets seen outside of the VA, compared to nonveterans. Further research is clearly warranted."         

Funded by the Centers for Disease Control and Prevention Foundation, the study utilized clinical and survey data from patients of four non-VA health care providers: Geisinger Health System, Danville, Pa.; Henry Ford Health System, Detroit, Mich.; Kaiser Permanente-Northwest, Portland, Ore.; and Kaiser Permanente-Hawaii, Honolulu.

About Geisinger Health System
Geisinger Health System is an integrated health services organization widely recognized for its innovative use of the electronic health record, and the development of innovative care models such as ProvenHealth Navigator® and ProvenCare®. As the nation's largest rural health services organization, Geisinger serves more than 2.6 million residents throughout 44 counties in central and northeastern Pennsylvania. The physician-led system is comprised of more than 20,800 employees, including a 1,000-member multi-specialty group practice, eight hospital campuses, two research centers and a 450,000-member health plan, all of which leverage an estimated $6.1 billion positive impact on the Pennsylvania economy. The health system and the health plan have repeatedly garnered national accolades for integration, quality and service. In addition to fulfilling its patient care mission, Geisinger has a long-standing commitment to medical education, research and community service. For more information, visit, or follow the latest Geisinger news and more on Twitter and Facebook.

Matthew Van Stone: 570-808-3248

SOURCE Geisinger System Services



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