October 4, 2013

Validated novel risk score developed to predict new onset end-stage renal disease

Provided by Medical News Today

Friday 4 October 2013 - 12am PST

End-stage renal disease is one of the major public health problems among solid organ transplant recipients that is associated with death after transplant and high cost of care.

Using the national data of 43,514 liver transplant recipients, researchers at University of Michigan researchers in collaboration with Arbor Research Collaborative for Health created and validated a risk score called renal risk index based upon the liver transplant recipient's characteristics at the time of transplant to predict the post- transplant end stage renal disease. Renal Risk Index was significantly associated with the higher 5-year cumulative incidence of post-transplant end stage renal disease and post-transplant death. The results were published in the Journal of the American Society of Nephrology.

"Our goal was to create a risk score based on the liver transplant recipient's factors to identify those who were at a higher risk of developing post-liver transplant end-stage renal disease," says Pratima Sharma, M.D., M.S., lead author of the study and assistant professor of Internal Medicine in the University of Michigan Medical School.

The renal risk index calculates a score by evaluating several recipient characteristics like age, race/ethnicity, history of hepatitis C, diabetes, BMI, serum creatinine levels and other factors. The renal risk index calculator is available here.

In addition to previously described risk factors, the study also identified body mass indexes (BMI) over 35 and hepatitis C as risk factor for post-transplant end-stage renal disease. Patients with BMI over 35 had a 28% increased risk of post-LT end stage renal disease compared to those with lower BMI. Diagnosis of hepatitis C was associated with 31% higher risk of post-transplant end stage renal disease compared to non-hepatitis C diagnoses. The study also showed that other factors, like serum sodium over 134 mEq/L at transplant were associated with a lower risk of post-transplant end-stage renal disease.

Sharma said the renal risk index is an objective score based upon readily available clinical and laboratory data that can help clinicians stratify liver transplant recipients into mild, moderate or high risk of post-liver transplant end-stage renal disease at the time of transplant.

"Knowledge of that future risk can help them reach making informed evidence-based decisions regarding post-transplant management including individualized tailoring of immunosuppression, stricter control of hypertension and diabetes, weight loss for obese patients as well as treatment of hepatitis C after transplant with newer antiviral agents," Sharma says.

"In the long run, risk stratification using renal risk index and risk modification among highest risk group can help prevent or delay the progression of kidney disease to end-stage renal disease and improve overall patient survival."

Sharma says future research should focus on using the renal risk index to personalize immunosuppression strategies and risk modification to improve patient outcomes.


Patient-Specific Prediction of ESRD after Liver Transplantation

Additional authors: Of the University of Michigan: Douglas E. Schaubel, Ph.D., Mary K. Guidinger, M.S., and Robert M. Merion, M.D. Of the Arbor Research Collaborative for Health: Nathan P. Goodrich, M.S, Robert M. Merion, M.D. JASN Published online before print September 12, 2013, doi: 10.1681/ASN.2013040436

Funding: Sharma is supported by National Institutes of Health Grant K08 DK-088946 and a research award from the American College of Gastroenterology. Schaubel was supported, in part, by National Institutes of Health Grant 5R01 DK-70869.

Disclosures: None

University of Michigan Health System


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Virological response rates for telaprevir-based hepatitis C triple therapy in patients with and without HIV coinfection

HIV Med. 2013 Sep 11. doi: 10.1111/hiv.12086. [Epub ahead of print]

Martel-Laferrière V, Brinkley S, Bichoupan K, Posner S, Stivala A, Perumalswami P, Schiano T, Sulkowski M, Dieterich D, Branch A.

Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.


OBJECTIVES: Pegylated-interferon/ribavirin dual therapy for hepatitis C virus (HCV) infection has a lower sustained virological response (SVR) rate in HIV/HCV-coinfected patients than in HCV monoinfected patients, but little is known about the relative effectiveness of teleprevir-based triple therapy in the two groups.

METHODS: Data on 33 coinfected and 116 monoinfected patients were analysed on an intention-to-treat basis. SVR12 was defined as undetectable HCV RNA at week 12 post-end-of-treatment, severe anaemia as haemoglobin ≤ 89 g/L or a drop of ≥ 45 g/L, and advanced fibrosis/cirrhosis as Fib-4 ≥ 3.25. All coinfected patients had well controlled HIV infection.

RESULTS: The groups were similar in age, gender, percentage with Fib-4 ≥ 3.25 and HCV viral load, but differed in previous treatment response, with more coinfected patients being nonresponders or treatment-intolerant (75.8% vs. 50.0% for monoinfected patients; P < 0.01). During treatment, the percentages of patients with undetectable HCV RNA were similar, but, surprisingly, this percentage tended to be higher in coinfected patients. SVR12 rates were 60.6% in coinfected patients vs. 42.2% in monoinfected patients (P = 0.06). In multivariable analysis, SVR12 was associated with HIV infection [odds ratio (OR) 3.55; P < 0.01], African American race (OR 0.37; P = 0.03) and previous treatment response (OR 0.46; P = 0.03). Rates of severe anaemia (45.5 vs. 58.6% in coinfected and monoinfected patients, respectively; P = 0.18) were similar in the two groups, but rash (15.2 vs. 34.5%, respectively; P = 0.03) and rectal symptoms (12.1 vs. 43.1%, respectively; P < 0.01) were less common in coinfected patients.

CONCLUSIONS: Virological responses of coinfected and monoinfected patients did not differ significantly, but tended to be higher in coinfected patients, who had a 60.6% SVR12 rate. Telaprevir-based triple therapy is a promising option for coinfected patients with well-controlled HIV infection.

© 2013 British HIV Association.

KEYWORDS: HIV, coinfection, hepatitis C virus, side effects, telaprevir

PMID: 24025147 [PubMed - as supplied by publisher]


Risk of Liver Decompensation Among HIV/HCV Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy

Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy


Clin Infect Dis. (2013) doi: 10.1093/cid/cit537 First published online: August 14, 2013

All Versions of this Article:
cit537v2 most recent

Juan Macías1, Manuel Márquez2, Francisco Téllez3, Dolores Merino4, Patricia Jiménez-Aguilar5, Luis F. López-Cortés6, Enrique Ortega7, Miguel A. von Wichmann8, Antonio Rivero9, María Mancebo1, Jesús Santos2, Montserrat Pérez-Pérez3, Ignacio Suárez-Lozano4, Alberto Romero-Palacios5, Almudena Torres-Cornejo6, and Juan A. Pineda1

+ Author Affiliations

Correspondence: Juan Antonio Pineda, MD, PhD, Infectious Diseases and Microbiology Unit, Hospital Universitario de Valme, Avda Bellavista s/n, Sevilla 41014, Spain (japineda@telefonica.net).


Background. Most human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–infected patients who are currently receiving boceprevir or telaprevir-based therapy against HCV show cirrhosis. However, the risk of liver decompensation (DC) among HIV/HCV-coinfected patients with stage 3 fibrosis in the short term could be high enough to not allow delays. We aimed at assessing the risk of DC among HIV/HCV-coinfected individuals with advanced fibrosis (F3–F4).

Methods. Eight hundred ninety-two HIV/HCV-coinfected patients, naive or without sustained virologic response to HCV therapy, were included in this cohort. Fibrosis was staged by biopsy in 317 patients and by liver stiffness measurement (LSM) in 575 individuals. Precirrhosis was defined as an LSM of 9.5–14.6 kilopascals (kPa), and cirrhosis as an LSM of ≥14.6 kPa.

Results. For patients with biopsy, the probability of remaining free of DC for F3 vs F4 was 99% (95% confidence interval [CI], 95%–100%) vs 96% (95% CI, 91%–98%) at 1 year, and 98% (95% CI, 94%–100%) vs 87% (95% CI, 81%–92%) at 3 years. The only factor independently associated with DC was fibrosis stage (F4 vs F3, subhazard ratio [SHR], 2.1; 95% CI, 1.07–4.1; P = .032). For patients with LSM, the probability of remaining free of DC for precirrhosis vs cirrhosis was 99% (95% CI, 96%–100%) vs 93% (95% CI, 89%–96%) at 1 year, and 97% (95% CI, 94%–99%) vs 83% (95% CI, 77%–87%) at 3 years. Factors independently associated with DC were platelet count (<100 × 103 vs ≥100 × 103: SHR, 1.86; 95% CI, 1.01–3.42; P = .046) and LSM (cirrhosis vs precirrhosis: SHR, 5.67; 95% CI, 2.27–14.1; P < .0001).

Conclusions. As in patients with cirrhosis, immediate therapy against HCV is warranted for patients with precirrhosis and HIV coinfection, as they are at risk of DC soon after the diagnosis of advanced fibrosis.

Key words: chronic hepatitis C, liver fibrosis, liver decompensations, liver biopsy, liver stiffness

Received April 19, 2013.
Accepted August 4, 2013.