October 25, 2010

Hepatitis C may play a role in ocular adnexal non-Hodgkin lymphoma

Posted on the OSN SuperSite October 25, 2010

Arch Ophthalmol. 2010;128(10):1295-1299.

The prevalence of hepatitis C infection may be relevant to ocular adnexal non-Hodgkin lymphoma, and hepatitis C may influence the initial appearance of the disease, a study said.

In the retrospective comparative study, medical records of 129 patients with ocular adnexal non-Hodgkin lymphoma were reviewed.

The prevalence of hepatitis C virus (HCV) infection among the patients was 17.8%, and seropositivity for infection was significantly associated with extraorbital lymphoma at the onset, the study said.

A high prevalence of mucosa-associated lymphoid tissue disease (79.8%) was also noted.

Ninety-nine patients who underwent radiotherapy and chemotherapy achieved complete remission, while 23.6% of patients with HCV-seronegative status and 21.7% of patients with HCV-seropositive status relapsed.

"However, the overall and disease-free survival of the infected patients are not statistically different than that of patients who are not infected," the authors said.


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