December 5, 2013

Age and gender differences in the relationship between hepatitis C infection and all stages of Chronic kidney disease

Journal of Viral Hepatitis

Early View (Online Version of Record published before inclusion in an issue)

Original Article

W.-C. Li1,*, Y.-Y. Lee2,3, I.-C. Chen4,5, S.-H. Wang6,7,8,9, C.-T. Hsiao4,5, S.-S. Loke10

Article first published online: 5 DEC 2013

DOI: 10.1111/jvh.12199

© 2013 John Wiley & Sons Ltd


Keywords: Chronic kidney disease;  creatinine;  eGFR;  hepatitis C virus;  proteinuria


Chronic kidney disease (CKD) is a worldwide health issue with heavy economic burden. Chronic hepatitis C virus (HCV) infection is a common cause of CKD, which can significantly impact the progression and mortality among patients with CKD. The prevalence of both illnesses is high in Taiwan. A multicentre and population-based cross-sectional study including 24 642 subjects was conducted to explore the association of HCV infection with the prevalence and severity of CKD. The measurements of metabolic parameters, eGFR and CKD stages were compared between subjects with HCV seropositivity and seronegativity. The analyses of association between HCV infection with CKD stages and evaluation of potential risk factors of CKD were performed by gender and age (≤ and >45 years). HCV-seropositive subjects accounted for 6.9% and had a significantly older age. The prevalence of CKD increased in those with HCV seropositivity (16.5%). Significantly higher prevalence of CKD stages ≥3 in HCV-seropositive subjects was noticed (7.8%). Age (>45 year), male gender, alcohol drinking, hypertension, creatinine and HCV infection were the significant factors associated with the presence of CKD. HCV seropositivity was an independent risk factor of developing CKD and associated with an increased risk of having CKD of all stages. The higher prevalence of earlier stage of CKD warrants longitudinal studies with frequent testing on renal function and sufficient duration to determine the changes of eGFR over time. Implementation of effective treatment intervention is also required for these subjects to prevent the progression of CKD to late stages.


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