January 7, 2014

Impulsiveness in chronic hepatitis C patients

General Hospital Psychiatry

Article in Press

Bruno Cópio Fábregas, MD, Mery Natali Silva Abreu, MD, PhD, Aieska Kellen Dantas dos Santos, MD, Alexandre Sampaio Moura, MD, PhD,  Ricardo Andrade Carmo, MD, PhD, Antônio Lúcio Teixeira, MD, PhD

Received 31 July 2013; received in revised form 19 November 2013; accepted 17 December 2013. published online 26 December 2013.
Accepted Manuscript



To investigate impulsiveness among chronic hepatitis C (CHC) patients and its association with sociodemographic, clinical, and psychopathological factors.


Ninety one CHC individuals were enrolled in a cross-sectional study at a Brazilian public university-based outpatient’s service for infectious diseases. They were assessed using Barrat Impulsiveness Scale, Brief Fatigue Inventory, Beck Depression Inventory and Hamilton Anxiety Scale. Structured psychiatric interview was performed according to the Mini International Neuropsychiatric Interview. Multivariate analysis was performed according to linear stepwise forward regression.


The total score of impulsiveness according to BIS in studied population was 64.6 ± 9.8. The scores for the non-planning, cognitive-attentional and motor domains were 23.8 ± 5, 19.4 ± 2.9, and 21.4 ± 5, respectively. Impulsiveness was associated with lower educational level, current IFN use, attention deficit hyperactivity disorder, alcohol use disorder, mixed anxiety and depressive disorder, specific phobia, bipolar spectrum disorders and anxiety symptoms. During IFN treatment, impulsiveness was also associated with suicide risk.


Impulsiveness was frequent in CHC patients and was associated with several psychopathological alterations. Impulsiveness management should be considered when attending CHC patients.

Keywords: Chronic hepatitis C, interferon-α, impulsive behavior, mental health


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