January 6, 2012

New study explains why hepatitis C virus is difficult to eliminate


Updated: 2012-01-05 16:56:58 CST

Individuals who have received a positive lab test for hepatitis C have a very high risk of experiencing liver problems, as there is currently no cure for the condition. However, a new study out of the University of North Carolina at Chapel Hill may help explain why the infection is so difficult to eliminate and points to the possibility of a new treatment .

The researchers found that the hepatitis C virus binds to a segment of genetic material in liver cells called microRNA-122. The molecule plays a role in regulating the reproduction of normal liver cells. When the virus attaches itself to this bit of genetic material, it is able to utilize it for the same purposes, ensuring consistent reproduction of the virus.

Findings from the investigation may play a role in the development of new medications that make it more difficult for the virus to replicate itself. The researchers said there is already an experimental drug in development that binds to microRNA-122, thereby preventing the virus from using it for its own purposes.
Given the high rates of the disease and significant burden of liver problems among those infected, the new medication could represent a major advance.


1 comment:

  1. There is a cure possible with the pegylated interferob ribavirin treatments. In the UK there is a clinical endpoint which if acheived is referred to and recognised as a cure. I have not read this article completely. but i disagree with the opening paragraph which states currently there is no cure.