July 23, 2013

Study shows HBV co-infections can predict prognosis

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Hepatitis B

Provided by Vaccine News Daily

Published on July 19, 2013 by Daniel Kamin

A group of scientists detailed the role of chronic hepatitis B co-infection in carcinogenesis of hepatitis C in a recent study published by PLOS ONE,.

A study was done on 115 liver tissues taken from the noncancerous parts of removed hepatitis C associated hepatocellular carcinoma. These samples were then given a virological analysis.

The results showed that occult and overt hepatitis B co-infection served as independent predictors for postoperative survival in HCV-associated HCC.

HCC is responsible for over 90 percent of liver malignancies and is the fifth most common solid cancer, as well as the third leading cause of cancer-related death. Around 75 percent of all HCCs are caused by HBV and HCV infections.

In the study, the clinical records of 342 HCC patients who had liver tumors removed from July 1998 to Aug 2001 were analyzed. Of the 342 patients, 115 tested positive for antibody HCV.

The results first showed that there was no significant difference between men and women in regards to HCV-associated HCC. Out of the 342 patients, 35 had overt HBVCI and 16 had detectable intrahepatic HBV DNA. This helped to show that occult, rather than overt, HBVCI led to a shorter postoperative disease-free survival in patients with HCV-associated HCC.

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