Gastroenterology. 2010 Sep 18. [Epub ahead of print]
Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, Landt CL, Harrison SA.
Gastroenterology and Hepatology Service, Department of Medicine; Brooke Army Medical Center.
Abstract
INTRODUCTION: The prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis (NASH).
METHODS: Outpatients 18 to 70 years old were recruited from Brooke Army Medical Center. All patients completed a baseline questionnaire and ultrasound. If fatty liver was identified, then laboratory data and a liver biopsy (LB) were obtained.
RESULTS: 400 patients were enrolled. 328 patients completed the questionnaire and ultrasound. Mean age (range 28-70) was 54.6 years (7.35); 62.5% Caucasian, 22% Hispanic, and 11.3% African American; 50.9% female; mean body mass index (BMI) was 29.8 kg/m(2) (5.64); diabetes and hypertension prevalence were 16.5% and 49.7% respectively. The prevalence of NAFLD was 46%. NASH was confirmed in 40 patients (12.2% of total cohort, 29.9% of ultrasound positive patients). Hispanics had the highest prevalence of NAFLD (58.3%), then Caucasians (44.4%) and African-Americans (35.1%). NAFLD patients were more likely to be male (58.9%), older (p=0.004), hypertensive (p<0.00005), and diabetic (p<0.00005). They had a higher BMI (p<0.0005), ate fast food more often (p=0.049) and exercised less (p=0.02), than their non-NAFLD counterparts. Hispanics had a higher prevalence of NASH compared with Caucasians (19.4% vs 9.8%, p=0.03). ALT, AST, BMI, insulin, QUICKI, and CK 18 correlated with NASH. Among the 54 diabetic patients, NAFLD was found in 74% and NASH in 22.2%.
CONCLUSION: The prevalence of NAFLD and NASH are higher than previously estimated. Hispanics and diabetic patients are at greatest risk for both NAFLD and NASH.
PMID: 20858492 [PubMed - as supplied by publisher]
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