Journal Archives of Gynecology and Obstetrics
Publisher Springer Berlin / Heidelberg
ISSN 0932-0067 (Print) 1432-0711 (Online)
Category General Gynecology
DOI 10.1007/s00404-010-1588-9
Subject Collection Medicine
SpringerLink Date Friday, July 23, 2010
Mohammad Ebrahim Ghamar Chehreh 1, Seyed Vahid Tabatabaei 1, Shahab Khazanehdari 1 and Seyed Moayed Alavian 1
(1) Research Center for Gastroenterology and Liver Disease, Ground floor of Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Mollasadra Ave., Vanak Sq., P.O. Box 14155-3651, Tehran, Iran
Received: 11 October 2009 Accepted: 5 July 2010 Published online: 21 July 2010
Abstract
Background
Hepatitis C virus (HCV) vertical transmission is considered the main route of HCV infection in children. Some authors have stated that cesarean section (C/S) can reduce perinatal HCV transmission. However, the study findings are heterogeneous and high-quality studies are lacking.
Aims
To evaluate the effect of mode of delivery on the risk of perinatal mother-to-infant transmission of HCV.
Methods
Only the peer-reviewed published studies that compared perinatal transmission rate of HCV in elective or emergency cesarean section with vaginal delivery in HCV-RNA+/HIV− mothers were included. We applied the random effect model of DerSimonian and Laird method with heterogeneity and sensitivity analyses.
Results
We identified 8 studies that involved 641 unique mother–infant pairs which fulfilled our inclusion criteria. Aggregation of study results did not show a significant decrease in HCV vertical transmission among study (mothers who underwent C/S) versus control (mothers who gave birth vaginally) patients [pooled odds ratio, 1.1 (95% CI 0.45–2.67)]. The P value was 0.35 for our test of heterogeneity.
Conclusions
Our meta-analysis suggests that C/S does not decrease perinatal HCV transmission from HCV-RNA+/HIV− mothers to infants.
Keywords Meta-analysis - HCV - Cesarean section - Vaginal delivery - Vertical transmission
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