September 15, 2013

Is 3 the new 1: perspectives on virology, natural history and treatment for hepatitis C genotype 3

Journal of Viral Hepatitis

Volume 20, Issue 10, pages 669–677, October 2013


E. B. Tapper1,2, N. H. Afdhal2,3,*

Article first published online: 8 SEP 2013

DOI: 10.1111/jvh.12168

© 2013 John Wiley & Sons Ltd


Keywords: alisporivir; cirrhosis; hepatic steatosis; interferon; ribavirin; sofosbuvir


Affecting 2–3% of the world's population, hepatitis C is a common viral infection which is a significant cause of morbidity and mortality. Hepatitis C genotype 1 is the dominant viral genotype among Western patients. For the last 20 years, in the era of interferon-based therapy, it was far more difficult to treat relative to genotypes 2 and 3. Accordingly, a significant focus of research was on new antiviral agents for the dominant genotype 1 patient. Now, as promising specific treatments are being introduced for genotype 1, the attention of clinicians and researchers has turned back to the 50–70 million patients infected with a nongenotype 1 hepatitis C. Furthermore, after recent, larger randomized trials, we have realized that genotype 2 is truly interferon sensitive while genotype 3 patients are far less successful with therapy. In this fundamentally altered landscape, genotype 3 is now potentially the most difficult to treat genotype and an area of intense research for new drug development. Herein we review the virology, natural history and the treatment of genotype 3 hepatitis C.


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