Impact of Coffee on Liver Diseases: A Systematic Review

Liver International

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Reviews

Sammy Saab^1,2,*,Divya Mallam³, Gerald A. Cox II², Myron Tong^1,2,4

DOI: 10.1111/liv.12304

This article is protected by copyright. All rights reserved.

Accepted manuscript online: 12 AUG 2013 07:54AM EST, Manuscript Revised: 5 AUG 2013, Manuscript Accepted: 5 AUG 2013, Manuscript Received: 3 JUN 2013

Keywords: Coffee; Liver disease

Abstract

Coffee is one of the most commonly consumed beverages in the world. Its health benefits including improved overall survival have been demonstrated in a variety of disease states. To examine the association of coffee consumption with liver disease, a systematic review of studies on the effects of coffee on liver associated laboratory tests, viral hepatitis, nonalcoholic fatty liver disease (NAFLD), cirrhosis and hepatocellular carcinoma (HCC) was performed.

Coffee consumption was associated with improved serum gamma glutamyltransferase, aspartate aminotransferase and alanine aminotransferase values in a dose dependent manner in individuals at risk for liver disease. In chronic liver disease patients who consume coffee, a decreased risk of progression to cirrhosis, a lowered mortality rate in cirrhosis patients, and a lowered rate of HCC development were observed. In chronic hepatitis C patients, coffee was associated with improved virologic responses to antiviral therapy. Moreover, coffee consumption was inversely related to the severity of steatohepatitis in patients with non-alcoholic fatty liver disease. Therefore, in patients with chronic liver disease, daily coffee consumption should be encouraged.

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