tag:blogger.com,1999:blog-2424607637992982887.post316618097306162726..comments2024-02-07T04:31:02.139-05:00Comments on HCV Research and News: Dietary Cholesterol Intake Is Associated With Progression of Liver Disease in Patients With Chronic Hepatitis C: Analysis of the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis TrialHepatitis C Research and Newshttp://www.blogger.com/profile/17201491048437787105noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2424607637992982887.post-60019236958374507822013-12-05T05:08:01.866-05:002013-12-05T05:08:01.866-05:00This is very flawed study based on questionnaires,...This is very flawed study based on questionnaires, overlooking many important confounding factors which may influence clinical and histological progression of liver disease in patients with hepatitis C, including virological factors (genotype), nutritional factors (type of fats, micronutrient and anitoxidant intakes), host factors (e.g. type of lipoproteins, ethnicity). Most importantly, prospective studies supports a role of low serum total and LDL-cholesterol and of oxidative stress as positive independent predictive factors of poor RVR in HCV patients. Coversely, high LDL- cholesterol and total cholesterol and lower triglycerides were were associated with higher rates of SVR. There is also significant amount of experimenatal and epidemiological evidence that omega-6 fatty acids increase progression of liver fibrosis. Michalhttps://www.blogger.com/profile/00429529681747820068noreply@blogger.comtag:blogger.com,1999:blog-2424607637992982887.post-6095658455559032052013-12-05T05:04:12.463-05:002013-12-05T05:04:12.463-05:00This is very flawed study based on questionnaires,...This is very flawed study based on questionnaires, overlooking many important confounding factors which may influence clinical and histological progression of liver disease in patients with hepatitis C, including virological factors (genotype), nutritional factors (type of fats, micronutrient and anitoxidant intakes), host factors (e.g. type of lipoproteins, ethnicity). Most importantly, prospective studies supports a role of low serum total and LDL-cholesterol and of oxidative stress as positive independent predictive factors of poor RVR in HCV patients. Coversely, high LDL- cholesterol and total cholesterol and lower triglycerides were were associated with higher rates of SVR. There is also significant amount of experimenatal and epidemiological evidence that omega-6 fatty acids increase progression of liver fibrosis. Michalhttps://www.blogger.com/profile/00429529681747820068noreply@blogger.com